Info: 60 Vegetable Capsules
Grape seed extract is a rich bioflavonoid which is used for fighting free radicals and maintaining capillary health. It can help relieve the symptoms of non-complicated Chronic Venous Insufficiency (CVI) such as tingling feelings or feelings of swelling or heaviness in the legs.
Info: 60 Vegetable Capsules
Grape seed extract is a rich bioflavonoid which is used for fighting free radicals and maintaining capillary health. It can help relieve the symptoms of non-complicated Chronic Venous Insufficiency (CVI) such as tingling feelings or feelings of swelling or heaviness in the legs.
Product Notes:
Free radicals do damage in the capillaries in two ways: (1) by inactivating a compound called a 1-antitripsin, whose role is to restrain the enzymes that break down collagen, elastin and hyaluronic acid, and (2) by turning the fats in the cell membranes rancid (lipid peroxidation).
Proanthocyanidins protect both the 1-antitripsin and the lipids by neutralizing the specific types of free radicals most likely to damage them, and may also directly inhibit the damaging enzymes. Collagen, elastin and hyaluronic acid make up much of the inner wall and supporting matrix of the capillaries; when they are in good shape the capillaries stretch to let red blood cells through the tight places and do not let the fluids in the blood leak out.
Proanthocyanidins
Proanthocyanidins (also known as leucoanthocyanidins) are a form of polyphenol, which is in turn a form of bioflavonoid. They are at least 15 to 25 times more powerful than vitamin E in neutralizing the iron and oxygen species free radicals that attack lipids.
Grapeseed extract is very similar to pine bark extract, with a high content of proanthocyanidins. Proanthocyanidins have shown a marked tendency to accumulate in tissues with high contents of glycosaminoglycans (complex amino sugars), such as capillary walls and skin. This may also apply to cartilage and synovial fluid. Proanthocyanidins have also shown antimutagenic effects in vitro at high concentrations (250 mcg/ml).
Grape seed extract is used for its free radical fighting capabilities, and for a variety of conditions related to capillary health and permeability. It is synergistic with vitamin C - which is more potent and absorbed more rapidly when used together with proanthocyanidins.
Proanthocyanidins have been indicated for: poor distribution of microcirculatory blood flow in the brain and heart; altered capillary fragility and permeability (in diabetes mellitus); chronic arterial/ venous insufficiency in the extremities; altered platelet aggregation and other characteristics of blood flow in capillaries; breakdown in the elastic fibers of the capillaries (collagen and elastin) due to free radical and enzyme action; microangiopathy of the retina, edema of the lymph nodes, varicose veins and other symptoms of the problems listed above; the cumulative effects of aging and reducing the risk of degenerative diseases.
Ingredients:
Each capsule contains:
500 mg Grape Seed Extract OPC (Vitis vinifera) (95% Proanthocyanidins)
100 mg Cranberry 107X Concentrate (Vaccinium macrocarpon)
Non-medicinal ingredients: Vegetable magnesium stearate in a non-GMO capsule composed of carbohydrate gum and purified water.
Contains no preservatives, sugar, dairy, wheat, corn, starch, soy, or yeast, or artificial flavours or colours.
Suggested Usage:
Take 1 to 2 capsules daily, or as directed by your healthcare professional.
For CVI (Chronic Venous Insufficiency), use for a minimum of 1 month.
Consult a healthcare practitioner for use beyond 3 months.
Warnings:
Keep out of reach of children. Consult a healthcare practitioner prior to using New Roots Grapeseed Extract if you are pregnant or breastfeeding; if you are taking any prescription medications (including blood thinners); if you have a history of kidney stones; or if you have been diagnosed for or are at risk for a blood pressure disorder.
Discontinue use for at least 2 weeks prior to surgery or dental procedures to prevent the risk of bleeding.
Health Canada Natural Product Number: 80035162.
Supporting Science:
Asbaghi, Omid et al. “The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials.” Phytotherapy Research: PTR, 2020.
Bagchi, Debasis et al. “Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview.” Mutation Research, 2014.
Sarkhosh-Khorasani, Sahar, and Mahdieh Hosseinzadeh. “The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials.” The British Journal of Nutrition, 2021.
Zhang, Haili et al. “The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials.” Medicine, 2016.